Institute of Medicine, Medical Follow-Up Agency, Committee's Advancing Prion Science: Guidance for the National Prion PDF

By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

ISBN-10: 0309090601

ISBN-13: 9780309090605

ISBN-10: 0309527147

ISBN-13: 9780309527149

Provides a document from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending examine to shut major gaps in current wisdom of prion ailments and strategies for strengthening the U.S. examine infrastructure for learning those illnesses. Softcover. DNLM: Prion illnesses, prevention & control--United States.

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Additional resources for Advancing Prion Science: Guidance for the National Prion Research Program

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1 liter of blood or 100 grams of beef). 2 Improve in vitro techniques that amplify small amounts of PrPSc to enhance the sensitivities of diagnostic tests. 3 Develop novel methods and reagents that detect or bind to prions, including new antibodies, peptides, nucleic acids, synthetic derivatives, and chimeric molecules. This research could lead not only to better diagnostics, but also to better therapeutic and prophylactic strategies. 4 Identify surrogate markers or signatures for the detection of prions or prion diseases.

Scientists can conduct. S. S. Department of Defense and the Department of Veterans Affairs. 3 REFERENCES APHIS (Animal and Plant Health Inspection Service). 2003. BSE Surveillance: Yearly Totals May 1990–FY 2003. [Online]. html [accessed June 18, 2003]. Belay ED, Maddox RA, Gambetti P, Schonberger LB. 2003. Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States. Neurology 60(2):176– 181. Brown P. 2001. Creutzfeldt-Jakob disease: blood infectivity and screening tests.

4: Fund research to identify surrogate markers or signatures for the detection of prions or prion diseases. , 2001). Analogous to the polymerase chain reaction technique for amplifying small amounts of DNA, these strategies could significantly boost the power of prion diagnostics. Cell Culture Assays In vitro culture systems have been used for prion detection with moderate success. Yet the committee believes these assays would hold great promise if a stable and robust cell culture assay were developed.

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Advancing Prion Science: Guidance for the National Prion Research Program by Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann


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