Read e-book online Antibiotic resistance : causes and risk factors, mechanisms PDF

By Adriel R. Bonilla

ISBN-10: 1607416239

ISBN-13: 9781607416234

ISBN-10: 1607419734

ISBN-13: 9781607419730

ISBN-10: 1616681624

ISBN-13: 9781616681623

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Extra info for Antibiotic resistance : causes and risk factors, mechanisms and alternatives

Sample text

Adherent probiotics could reduce the viability of pathogenic bacteria. Manley et al. (2007) has proposed that competition for nutrients by probiotics could be a potential mechanism to clear intestinal infections. Under normal physiology, the gastrointestinal tract is such a rich source of nutrients that it may seem unfeasible that such mechanism could influence the composition of the gut microflora. Nevertheless, it only requires the absence of one limiting essential nutrient to trigger this mechanism.

The production of these antimicrobial factors in the gut would have an antagonistic effect on the resistant strains, which would confer a competitive advantage to the bacteriocin-producing bacteria in the microenvironment. , 2008). Therefore, it is expected that bacteriocin-producing probiotics could reduce the colonization by antibiotic-resistant strains. Past studies have demonstrated that strains of L. , 2008). The bacteriocin and other antimicrobial peptides 12 Min-Tze Liong, Siok-Koon Yeo, Chiu-Yin Kuan et al.

Furthermore, more than half of the tested strains showed slight resistance to tetracycline. Recently, several antibiotic-resistant probiotic and starters culture strains have also been isolated from dairy and pharmaceutical products by D’Aimmo et al. (2007). Among the 34 strains of Lactobacillus and Bifidobacterium, and 21 strains of starter culture bacteria, all tested strains were resistant to aztreonam, cycloserin, kanamycin, nalidixic acid, polymyxin B and spectinomycin with MIC90s (lowest antibiotic concentration that inhibited 90% of the tested strains) ranging from 64 to >1000 µg/ml.

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Antibiotic resistance : causes and risk factors, mechanisms and alternatives by Adriel R. Bonilla


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