By Kenneth J. Olivier Jr., Sara A. Hurvitz
Providing useful and confirmed recommendations for antibody-drug conjugate (ADC) drug discovery luck in oncology, this e-book is helping readers enhance the drug safeguard and healing efficacy of ADCs to kill specified tumor cells.
• Discusses the fundamentals, drug supply options, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case stories of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC examine and development
Read Online or Download Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer PDF
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Additional resources for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer
Cell 1977;12:663–73. Milstein C, Lennox E. The use of monoclonal antibody techniques in the study of development cell surfaces. Current Topics in Developmental Biology 1980;14:1–32. Ritz J, Schlossman SF. Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 1982;59:1–11. Macek C Monoclonal antibodies: key to a revolution in clinical medicine. JAMA 1982;247:2463–70. xxxi xxxii Historical Perspective: What Makes Antibody–Drug Conjugates Revolutionary? 10 Goldenberg DM, Kim EE, DeLand FH, Bennett S, Primus FJ.
4 Potential cell-killing mechanisms for an ADC. Illustration of the mechanisms by which an ADC can effect cell death. For some targets and some antibodies, only the payload delivery mechanism of cell killing is operative. For other targets and antibodies, one or more of the biologic or immunologic mechanisms may also contribute to the overall activity of an ADC. ) Apart from specificity for their target, antibodies should bind with sufficient affinity for good retention at the tumor in vivo. 0 nM.
6). , see reference ). However, selecting the correct site in the antibody molecule up front is not trivial , and furthermore, having 100% of the modification at a single site could potentially increase the possibility of an adverse immune response to the ADC. Several ADCs made using site-specific cysteine conjugation have recently entered clinical trials (structures are disclosed for four such “site-specific” ADCs at time of writing). There are a variety of other site-specific conjugation approaches that are being evaluated in the research laboratory [53, 59, 60]; however, a detailed description of these approaches is beyond the scope of this chapter and is about “typical” ADCs at this time.
Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer by Kenneth J. Olivier Jr., Sara A. Hurvitz