By André Bryskier
Annotation Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released by way of Ellipses in 1999. bargains thousands of antibiotics and antimicrobial compounds: in improvement, experimental, and in useProvides a radical replace of the unique French version released in 1999, plus severe new materialPresents complete assurance of chemistry and synthesis, class, constitution & ndash;activity relationships, mechanisms of motion and resistance, breakpoints, in vitro/in vivo actions, epidemiology, pharmacokinetics, metabolism, and adversarial eventsFeatures over 1,200 illustrations, over 1,500 tables, and greater than 3,000 referencesPresents new, huge chapters protecting helicobacter pylori and methicillin & ndash;resistant Staphylococcus aureus (MSRA). �Read more...
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Additional resources for Antimicrobial agents : antibacterials and antifungals
The credit for demonstrating the antibacterial activity of sulfamidochrysoidine in vivo in the treatment of experimental streptococcal septicemia, despite the fact that the substance was inactive in vitro, goes to Gerhard Domagk. A few months later, J. Tréfouël and his team showed that sulfamidochrysoidine was metabolized and that only the para-aminophenylsulfonamide moiety was active. In 1935, F. M. Mietzch and P. Klave synthesized a series of amino dyes comprising the sulfonamide group, including Prontosil and Rubiazol, which have been used since 1936 in the treatment of infectious diseases.
While at the same time retaining the microbiological properties provided by molecules such as cefpirome and cefepime. A number of derivatives containing a catechol or pyridone nucleus linked to the oxyimine chain that have not progressed beyond the preclinical stage possess a supplementary and original mechanism of action. In addition to the standard transporin pathway, they employ iron siderophore transporters to penetrate the bacterial wall. Cephalosporins exhibiting antistaphylococcal activity against strains resistant to methicillin have been produced and are currently under development.
These related in particular to syphilis. In 1496 Ulsenius asserted its contagiousness, and then in about 1519 Van Hutten proposed “small winged worms” and Paracelsus “small living organisms” as causative agents. These ideas, although disputed by the majority of doctors, led to prophylactic measures being taken; thus, from 1500 onwards, certain Italian towns instituted health screening of prostitutes. The ﬁrst great precursor of bacteriologists was the physician and poet Girolamo Frascator of Verona, Italy.
Antimicrobial agents : antibacterials and antifungals by André Bryskier