Download e-book for iPad: Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina

By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the kingdom of the technology with twenty studies that learn the most recent in today’s antiviral drug discovery efforts.

  • Presents the basic rules of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes medical features of viral an infection with reference to remedy and toxicity.
  • Examines recognized and capability pursuits in any respect levels of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a wide diversity of viruses, together with HIV-1, HSV, and HCV.

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Darlison, K. Edmonds, R. M. Perkins, and R. A. Vere Hodge. 1992. Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus. Antimicrob. Agents Chemother. 36:2747–2757. 45. , S. Kemp, G. Darby, and A. C. Minson. 1989. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 70:869–879. 46. Elion, G. , P. A. Furman, J. A. Fyfe, P. de Miranda, L. Beauchamp, and H. J. Schaeffer. 1977. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine.

Moss. 1995. UL protein kinases (Herpesviruses), p. 391–393. In D. G. Hardie and S. ), The Protein Kinase Facts Book, vol. 1. Academic Press, London, United Kingdom. 109. McGuirt, P. , J. E. Shaw, G. B. Elion, and P. A. Furman. 1984. Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir. Antimicrob. Agents Chemother. 25:507–509. 110. Mertz, G. , C. W. Critchlow, J. Benedetti, R. C. Reichman, R. Dolin, J. Connor, D. C. Redfield, M. C.

Virol. 81:6817–6826. 155. Wang, T. S. F. 1996. Cellular DNA polymerases, p. 461–493. In M. L. ), DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 156. , A. A. Kuo, G. R. Painter, L. L. Wright, P. A. Furman, and D. M. Coen. 1993. Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Proc. Natl. Acad. Sci. USA 90:1028–1032. ) 157. Whitley, R. , J. W. , D. Hinthorn, C. Liu, R. B. Pollard, F. Hayden, G. J. Mertz, M. Oxman, and S.

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